Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15202446 | 0.91 | CTSS (0.46) | CTSSGPR119MEN1KMT2AAR | |
| SCHEMBL697268 | 0.83 | CTSS (0.47) | CTSSGPR119MEN1KMT2AAR | |
| SCHEMBL696064 | 0.82 | CTSS (0.42) | CTSSGPR119 | |
| SCHEMBL696555 | 0.81 | UCHL1 (0.36) | CTSSGPR119MEN1KMT2AAR | |
| SCHEMBL15202564 | 0.80 | CTSS (0.42) | CTSSGPR119MEN1KMT2AAR | |
| SCHEMBL15200629 | 0.80 | CTSS (0.47) | CTSSGPR119ARUCHL1USP30 | |
| SCHEMBL695135 | 0.79 | UCHL1 (0.36) | CTSSGPR119ARUCHL1USP30 | |
| SCHEMBL2105362 | 0.78 | CTSS (0.55) | CTSS | |
| SCHEMBL693999 | 0.77 | CTSS (0.48) | CTSS | |
| SCHEMBL695949 | 0.77 | CTSS (0.41) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |