Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15202564 | 0.86 | CTSS (0.42) | UCHL1ALDH1A1USP30STSGRM5 | |
| SCHEMBL15202446 | 0.83 | CTSS (0.46) | UCHL1USP30GPR119CTSSAR | |
| SCHEMBL694346 | 0.83 | STS (0.44) | UCHL1STSCTSS | |
| SCHEMBL15200629 | 0.82 | CTSS (0.47) | UCHL1USP30GPR119CTSSAR | |
| SCHEMBL695061 | 0.81 | CTSS (0.44) | STSCTSS | |
| SCHEMBL696555 | 0.81 | UCHL1 (0.36) | UCHL1TSHRUSP30GPR119CTSS | |
| SCHEMBL697268 | 0.80 | CTSS (0.47) | UCHL1USP30GPR119CTSSJAK2 | |
| SCHEMBL695044 | 0.79 | CTSS (0.38) | UCHL1USP30GPR119CTSSAR | |
| SCHEMBL697169 | 0.78 | CTSS (0.50) | CTSS | |
| SCHEMBL15200555 | 0.78 | STS (0.47) | UCHL1USP30STSGRM5CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |