Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 6/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | MME | P08473 | 2/20 | 0.53 |
| ▸ | ECE1 | P42892 | 2/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.53 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGAV | P06756 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13324010 | 0.89 | SIRT2 (0.61) | FOLH1SIRT2SIRT1CAPN1CAPN2 | |
| SCHEMBL19307785 | 0.89 | FOLH1 (0.64) | FOLH1SIRT2SIRT1MMEECE1 | |
| SCHEMBL9697060 | 0.89 | FOLH1 (0.64) | FOLH1SIRT2SIRT1MMEECE1 | |
| SCHEMBL19925534 | 0.89 | FOLH1 (0.64) | FOLH1SIRT2SIRT1MMEECE1 | |
| SCHEMBL9698236 | 0.89 | FOLH1 (0.64) | FOLH1SIRT2SIRT1MMEECE1 | |
| SCHEMBL24238520 | 0.89 | FOLH1 (0.64) | FOLH1SIRT2SIRT1MMEECE1 | |
| SCHEMBL910233 | 0.88 | FOLH1 (0.70) | FOLH1SIRT2SIRT1MMEECE1 | |
| SCHEMBL910232 | 0.88 | FOLH1 (0.70) | FOLH1SIRT2SIRT1MMEECE1 | |
| SCHEMBL910423 | 0.88 | FOLH1 (0.70) | FOLH1SIRT2SIRT1MMEECE1 | |
| Benzene SCHEMBL28226069 | 0.88 | FOLH1 (0.70) | FOLH1SIRT2SIRT1MMEECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758328-B1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INT LTD (GB) | 2003-07-16 | — | — | EP | disclosed |
| EP-0758328-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INTERNATIONAL LIMITED (GB) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030673-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |