Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.61 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.58 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.55 |
| ▸ | ITGAV | P06756 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950440 | 0.89 | FOLH1 (0.64) | SIRT2SIRT1CAPN1CAPN2FOLH1 | |
| SCHEMBL13324011 | 0.89 | SIRT2 (0.53) | SIRT2SIRT1CAPN1CAPN2FOLH1 | |
| SCHEMBL14077190 | 0.88 | CAPN1 (0.55) | SIRT2SIRT1CAPN1CAPN2FOLH1 | |
| SCHEMBL13323984 | 0.87 | SIRT2 (0.50) | SIRT2SIRT1CAPN1CAPN2FOLH1 | |
| SCHEMBL7574171 | 0.86 | FOLH1 (0.54) | SIRT2SIRT1CAPN1CAPN2FOLH1 | |
| SCHEMBL13324029 | 0.86 | SIRT2 (0.49) | SIRT2SIRT1CAPN1CAPN2FOLH1 | |
| SCHEMBL329038 | 0.85 | CTSK (0.66) | SIRT2SIRT1CTSLCTSSCTSK | |
| SCHEMBL265461 | 0.85 | CTSK (0.66) | SIRT2SIRT1CTSLCTSSCTSK | |
| SCHEMBL265783 | 0.85 | CTSK (0.66) | SIRT2SIRT1CTSLCTSSCTSK | |
| SCHEMBL23519310 | 0.85 | SIRT2 (0.81) | SIRT2SIRT1FOLH1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012153125-A1 | NOVEL COMPOUNDS AND METHODS FOR USE IN MEDICINE | ASTON UNIVERSITY (GB) | 2012-11-15 | — | — | WO | disclosed |
| US-7723307-B2 | Amino acid derivatives and pharmaceutical uses thereof | ASTON UNIVERSITY (GB) | 2010-05-25 | — | — | US | disclosed |
| US-7723307-B2 | Amino acid derivatives and pharmaceutical uses thereof | ASTON UNIVERSITY (GB) | 2010-05-25 | — | — | US | disclosed |
| US-20080200511-A1 | Novel Compounds and Methods of Using the Same | ASTON UNIVERSITY (GB) | 2008-08-21 | — | — | US | disclosed |
| US-20080200511-A1 | Novel Compounds and Methods of Using the Same | ASTON UNIVERSITY (GB) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200511-A1 | Novel Compounds and Methods of Using the Same | F3, IL4I1, TPMT | SIRT2 2625/4885SIRT1 2314/4885CAPN1 3217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.