Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 4/20 | 0.57 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 13/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8593203 | 0.82 | TACR2 (0.55) | TACR2CCR5TACR1 | |
| SCHEMBL6957564 | 0.81 | TACR2 (0.54) | TACR2CCR5TACR1ALDH1A1 | |
| SCHEMBL8291262 | 0.81 | CCR5 (0.51) | TACR2CCR5TACR1 | |
| SCHEMBL6947096 | 0.80 | TACR2 (0.60) | TACR2CCR5TACR1 | |
| SCHEMBL6953772 | 0.80 | TACR2 (0.58) | TACR2CCR5TACR1ALDH1A1 | |
| SCHEMBL8300796 | 0.80 | TACR1 (0.59) | TACR2CCR5TACR1 | |
| SCHEMBL6950737 | 0.78 | TACR2 (0.45) | TACR2CCR5ALDH1A1CCR1 | |
| SCHEMBL6955458 | 0.78 | TACR2 (0.90) | TACR2TACR1 | |
| SCHEMBL7956549 | 0.78 | TACR1 (0.49) | CCR5TACR1 | |
| SCHEMBL8292201 | 0.77 | TACR2 (0.57) | TACR2CCR5TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| US-6242438-B1 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists | PFIZER INC. | 2001-06-05 | — | — | US | disclosed |