Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 4/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950730 | 0.78 | TACR2 (0.57) | TACR2ALDH1A1CCR1CCR5 | |
| SCHEMBL8311382 | 0.74 | SLC6A2 (0.41) | CYP3A4CYP2D6CYP1A2KCNH2SLC6A2 | |
| SCHEMBL8315731 | 0.73 | SLC6A3 (0.40) | CYP3A4CYP2D6CYP1A2CYP2C19KCNH2 | |
| SCHEMBL8310465 | 0.72 | SLC6A3 (0.37) | CYP3A4CYP2D6CYP1A2KCNH2SLC6A2 | |
| SCHEMBL8315887 | 0.72 | SLC6A3 (0.38) | CYP3A4CYP2D6CYP1A2KCNH2SLC6A2 | |
| SCHEMBL8882804 | 0.68 | SLC6A3 (0.36) | CYP3A4CYP2D6CYP1A2KCNH2SLC6A2 | |
| SCHEMBL9027072 | 0.68 | SLC6A3 (0.35) | CYP3A4CYP2D6CYP1A2KCNH2SLC6A2 | |
| SCHEMBL6957564 | 0.67 | TACR2 (0.54) | TACR2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL6953772 | 0.67 | TACR2 (0.58) | TACR2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL6955458 | 0.66 | TACR2 (0.90) | TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| US-6242438-B1 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists | PFIZER INC. | 2001-06-05 | — | — | US | disclosed |