SCHEMBL6950775

SCHEMBL6950775

Nc1ncc2ncn(Cc3ccc4[nH]ccc4c3)c2n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.53
HSP90AA1 P07900 1/20 0.43
HSP90AB1 P08238 1/20 0.43
ADORA2A P29274 4/20 0.43
ADORA1 P30542 2/20 0.43
ADORA2B P29275 2/20 0.43
ADORA3 P0DMS8 1/20 0.43
MET P08581 6/20 0.40
AKT1 P31749 1/20 0.38
PIK3CA P42336 1/20 0.38
MTOR P42345 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
ADRA1A P35348 1/20 0.37
HSD17B10 Q99714 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
FGFR1 P11362 1/20 0.36
FGFR4 P22455 1/20 0.36
CYP3A4 P08684 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6945092 0.76 HDAC6 (0.64) HDAC6HSP90AA1HSP90AB1ADORA2AKDM4E
SCHEMBL6948194 0.75 HSP90AA1 (0.45) HDAC6HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL28299548 0.75 HDAC6 (0.63) HDAC6HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL6939917 0.74 HDAC6 (0.56) HDAC6HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL6947944 0.74 ALDH1A1 (0.56) HDAC6HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL6946592 0.74 HDAC6 (0.62) HDAC6HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL3269254 0.73 ADORA2A (0.75) ADORA2AADORA1ADORA2BADORA3
SCHEMBL6941912 0.73 HDAC6 (0.60) HDAC6HSP90AA1HSP90AB1ADORA2AMET
SCHEMBL7077177 0.71 ADORA2A (0.58) HDAC6HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL6944465 0.71 HDAC6 (0.55) HDAC6HSP90AA1HSP90AB1ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1349857-A1 PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2003-10-08 EP disclosed
WO-2002055521-A1 PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2002-07-18 WO disclosed