Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.37 |
| ▸ | TUBB | P07437 | 2/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6762758 | 0.88 | MAPK8 (0.37) | MAPK8MAPK9MAPK10LMNASMN1; SMN2 | |
| SCHEMBL6948979 | 0.79 | KDM4E (0.44) | SMN1; SMN2MAPK1BRD4ALDH1A1MAPT | |
| SCHEMBL5753766 | 0.76 | ALDH1A1 (0.42) | MAPK8MAPK9MAPK10LMNASMN1; SMN2 | |
| SCHEMBL5754985 | 0.76 | ALDH1A1 (0.42) | LMNASMN1; SMN2GAAMAPK1BRD4 | |
| SCHEMBL424184 | 0.75 | ALDH1A1 (0.47) | LMNASMN1; SMN2GAAMAPK1ALDH1A1 | |
| SCHEMBL6943425 | 0.74 | TUBB4A (0.39) | LMNASMN1; SMN2GAAMAPK1BRD4 | |
| SCHEMBL7655446 | 0.74 | KMT2A (0.41) | MAPK8MAPK9MAPK10LMNASMN1; SMN2 | |
| SCHEMBL7011428 | 0.73 | MAPK8 (0.43) | MAPK8MAPK9MAPK10LMNASMN1; SMN2 | |
| SCHEMBL6376780 | 0.73 | ALDH1A1 (0.42) | LMNASMN1; SMN2GAAMAPK1ALDH1A1 | |
| SCHEMBL6772390 | 0.72 | ABCB1 (0.42) | LMNASMN1; SMN2GAAMAPK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887344-B1 | Quinolines and quinazolines useful in therapy | PFIZER LTD (GB) | 2003-12-03 | — | — | EP | disclosed |
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |