Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951305 | 0.80 | MGAT2 (0.60) | ALDH1A1PKMSMN1; SMN2POLBHPGD | |
| SCHEMBL14111832 | 0.80 | ALDH1A1 (0.58) | ALDH1A1PKMKMT2ASMN1; SMN2GAA | |
| SCHEMBL7812463 | 0.76 | MGAT2 (0.56) | ALDH1A1PKMSMN1; SMN2POLBHPGD | |
| SCHEMBL26538720 | 0.74 | ALDH1A1 (0.61) | ALDH1A1PKMKMT2ASMN1; SMN2GAA | |
| SCHEMBL25248439 | 0.74 | KMT2A (0.68) | ALDH1A1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL31490088 | 0.73 | ATM (0.64) | ALDH1A1PKMKMT2ASMN1; SMN2GAA | |
| SCHEMBL23768821 | 0.73 | ATM (0.64) | ALDH1A1PKMKMT2ASMN1; SMN2GAA | |
| SCHEMBL6949092 | 0.73 | HTR2C (0.54) | ALDH1A1KMT2ASMN1; SMN2MEN1PKLR | |
| SCHEMBL6943633 | 0.72 | ALDH1A1 (0.58) | ALDH1A1PKMKMT2ASMN1; SMN2GAA | |
| SCHEMBL28221694 | 0.72 | KMT2A (0.68) | ALDH1A1PKMKMT2ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |