Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.51 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.51 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951305 | 0.95 | MGAT2 (0.60) | MGAT2LMNASLC12A2SLC12A5PKLR | |
| SCHEMBL6954051 | 0.82 | PKLR (0.55) | MGAT2PKLRPOLBALDH1A1TP53 | |
| SCHEMBL30555219 | 0.82 | PKLR (0.55) | MGAT2PKLRPOLBALDH1A1TP53 | |
| SCHEMBL7354552 | 0.78 | KEAP1 (0.69) | LMNASLC12A2SLC12A5PKMKEAP1 | |
| SCHEMBL6950845 | 0.76 | ALDH1A1 (0.57) | PKLRPKMPOLBALDH1A1L3MBTL1 | |
| SCHEMBL6949092 | 0.75 | HTR2C (0.54) | LMNAPKLRALDH1A1TP53CA9 | |
| SCHEMBL6948216 | 0.75 | ALDH1A1 (0.58) | MGAT2PKLRPOLBALDH1A1CYP1A2 | |
| SCHEMBL6954621 | 0.74 | MEN1 (0.64) | LMNASLC12A2SLC12A5PKMPOLB | |
| SCHEMBL1092244 | 0.74 | MGAT2 (0.65) | MGAT2LMNASLC12A2SLC12A5PKM | |
| SCHEMBL6946099 | 0.73 | TBXAS1 (0.49) | PKLRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BECKMAN CORP (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-0988035-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1999006042-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |