Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | PARG | Q86W56 | 1/20 | 0.53 |
| ▸ | PKLR | P30613 | 1/20 | 0.53 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954313 | 0.83 | ALDH1A1 (0.60) | SMN1; SMN2LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6951305 | 0.79 | MGAT2 (0.60) | PKLRCA9SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2203522 | 0.76 | SMYD3 (0.59) | HTR2CHTR2BPARGLMNATP53 | |
| SCHEMBL6943633 | 0.75 | ALDH1A1 (0.58) | PKLRSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL7812463 | 0.75 | MGAT2 (0.56) | PKLRCA9SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6954051 | 0.74 | PKLR (0.55) | PKLRCA1CA2CA9KMT2A | |
| SCHEMBL30555219 | 0.74 | PKLR (0.55) | PKLRCA1CA2CA9KMT2A | |
| SCHEMBL6950254 | 0.73 | PKLR (0.50) | PARGPKLRCA1CA2HDAC8 | |
| SCHEMBL6947428 | 0.73 | PKLR (0.52) | PKLRSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL6950845 | 0.73 | ALDH1A1 (0.57) | PKLRSMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |