Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8093570 | 0.90 | ADRA2A (0.49) | ADRA2ACYP1A2CYP2D6CYP2C19 | |
| Fumaric Acid SCHEMBL8093564 | 0.90 | ADRA2A (0.49) | ADRA2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6954690 | 0.80 | SLC6A2 (0.41) | ADRA2ACYP1A2CYP2A6CYP3A4CYP2D6 | |
| SCHEMBL3441406 | 0.72 | CYP2D6 (0.51) | ADRA2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6957391 | 0.71 | SLC6A2 (0.39) | ADRA2ACYP1A2CYP2A6SLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL8084690 | 0.71 | TBXA2R (0.43) | CYP1A2CYP3A4CYP2D6CYP2C9SLC6A2 | |
| Fumaric Acid SCHEMBL8084695 | 0.71 | TBXA2R (0.43) | CYP1A2CYP3A4CYP2D6CYP2C9SLC6A2 | |
| SCHEMBL8093566 | 0.70 | ADRA2A (0.46) | ADRA2A | |
| SCHEMBL3441576 | 0.70 | ADRA2A (0.42) | ADRA2A | |
| SCHEMBL3441577 | 0.70 | ADRA2A (0.42) | ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | claimed |
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | claimed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | claimed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | claimed |
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |