Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8084690 | 0.88 | TBXA2R (0.43) | SLC6A2SLC6A4SLC6A3CYP1A2KCNH2 | |
| Fumaric Acid SCHEMBL8084695 | 0.88 | TBXA2R (0.43) | SLC6A2SLC6A4SLC6A3CYP1A2KCNH2 | |
| SCHEMBL6957391 | 0.84 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP1A2CYP2A6 | |
| SCHEMBL3441782 | 0.80 | ADRA2A (0.42) | TAAR1ADRA2A | |
| SCHEMBL3441577 | 0.80 | ADRA2A (0.42) | TAAR1ADRA2A | |
| SCHEMBL11821505 | 0.74 | SLC6A4 (0.49) | SLC6A2SLC6A4SLC6A3CYP1A2KCNH2 | |
| Fumaric Acid SCHEMBL8093564 | 0.72 | ADRA2A (0.49) | CYP1A2CYP2D6TAAR1CYP2C19ADRA2A | |
| SCHEMBL3441406 | 0.72 | CYP2D6 (0.51) | CYP1A2CYP2D6TAAR1CYP2C9CYP2C19 | |
| SCHEMBL28262128 | 0.72 | CYP1A2 (0.44) | SLC6A2SLC6A4SLC6A3CYP1A2CYP2A6 | |
| SCHEMBL31392630 | 0.71 | SLC6A4 (0.57) | SLC6A2SLC6A4SLC6A3CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |