Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.37 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGFR | P43088 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8084695 | 1.00 | TBXA2R (0.43) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL6954690 | 0.88 | SLC6A2 (0.41) | CYP1A2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Fumaric Acid SCHEMBL8093552 | 0.87 | CCR3 (0.37) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| Fumaric Acid SCHEMBL8093561 | 0.87 | CCR3 (0.37) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| Fumaric Acid SCHEMBL8093564 | 0.84 | ADRA2A (0.49) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| Fumaric Acid SCHEMBL8093570 | 0.84 | ADRA2A (0.49) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| Fumaric Acid SCHEMBL8092928 | 0.78 | ADRA2A (0.46) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| Fumaric Acid SCHEMBL8092925 | 0.78 | ADRA2A (0.46) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL6957391 | 0.74 | SLC6A2 (0.39) | CYP1A2SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3441576 | 0.73 | ADRA2A (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |