Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4218122 | 0.90 | CSF1R (0.53) | AKR1C3AKR1C2PTGS2CSF1R | |
| SCHEMBL21327632 | 0.82 | AKR1C3 (0.65) | CLCN2AKR1C3AKR1C2 | |
| SCHEMBL848085 | 0.81 | AKR1C3 (0.60) | CLCN2AKR1C3AKR1C2JAK2JAK1 | |
| SCHEMBL30294732 | 0.80 | CLCN2 (0.48) | CLCN2PTGS2LMNA | |
| SCHEMBL22853344 | 0.80 | CLCN2 (0.48) | CLCN2PTGS2LMNA | |
| SCHEMBL6944176 | 0.80 | AKR1C3 (0.48) | CLCN2AKR1C3AKR1C2 | |
| SCHEMBL6950478 | 0.79 | AKR1C3 (0.50) | CLCN2AKR1C3AKR1C2 | |
| SCHEMBL13890925 | 0.77 | CSF1R (0.51) | PTGS2CSF1R | |
| SCHEMBL4209141 | 0.76 | SOS1 (0.54) | SOS1PTGS2 | |
| SCHEMBL4229254 | 0.76 | ACLY (0.48) | AKR1C3AKR1C2PTGS2CSF1RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | disclosed |
| CN-1365277-A | Methods of treating chronic pain using MEK inhibitors | VARNER LAMBERT CO (US) | 2002-08-21 | — | — | CN | disclosed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |