Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 13/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.48 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946239 | 0.83 | CLCN2 (0.50) | AKR1C3AKR1C2CLCN2GRIK1MEN1 | |
| SCHEMBL21327632 | 0.81 | AKR1C3 (0.65) | AKR1C3AKR1C2CLCN2MEN1KMT2A | |
| SCHEMBL6951978 | 0.80 | CLCN2 (0.51) | AKR1C3AKR1C2CLCN2 | |
| SCHEMBL848085 | 0.79 | AKR1C3 (0.60) | AKR1C3AKR1C2CLCN2GRIK1MPO | |
| SCHEMBL6950478 | 0.78 | AKR1C3 (0.50) | AKR1C3AKR1C2CLCN2GRIK1MEN1 | |
| SCHEMBL1415570 | 0.74 | MAPT (0.56) | AKR1C3AKR1C2GRIK1MEN1KMT2A | |
| SCHEMBL26596770 | 0.74 | AKR1C3 (0.58) | AKR1C3AKR1C2CLCN2GRIK1MPO | |
| SCHEMBL4226484 | 0.74 | XDH (0.54) | AKR1C3AKR1C2GRIK1MAPTGFER | |
| SCHEMBL14392041 | 0.74 | AKR1C3 (0.51) | AKR1C3AKR1C2CLCN2GRIK1MAPT | |
| SCHEMBL7833932 | 0.73 | AKR1C3 (0.44) | AKR1C3AKR1C2CLCN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | disclosed |
| CN-1365277-A | Methods of treating chronic pain using MEK inhibitors | VARNER LAMBERT CO (US) | 2002-08-21 | — | — | CN | disclosed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |