Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.60 |
| ▸ | FABP4 | P15090 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 2/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.53 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26596770 | 0.90 | AKR1C3 (0.58) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL4213857 | 0.89 | AKR1C3 (0.56) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL7844253 | 0.87 | AKR1C3 (0.51) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL14598924 | 0.86 | MAPT (0.65) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL21327632 | 0.85 | AKR1C3 (0.65) | AKR1C3AKR1C2MAPTGFERCLCN2 | |
| SCHEMBL6141327 | 0.85 | FABP4 (0.62) | AKR1C3AKR1C2MAPTFABP4MPO | |
| SCHEMBL1958267 | 0.84 | MAPT (0.67) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL27570509 | 0.84 | GRIK1 (0.46) | AKR1C3AKR1C2MAPTGFERNGLY1 | |
| SCHEMBL14576318 | 0.83 | GRIK1 (0.54) | AKR1C3AKR1C2MAPTFABP4GRIK1 | |
| SCHEMBL4215664 | 0.83 | ACLY (0.52) | AKR1C3AKR1C2MAPTGFERNGLY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116903613-A | 2-oxo quinazoline five-membered heterocyclic derivative, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-109516946-B | Method for preparing carbazole compound | 上海交通大学 | 2022-01-11 | — | — | CN | disclosed |
| EP-2731932-B1 | AMINOMETHYL QUINOLONE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-12-30 | — | — | EP | disclosed |
| EP-2731932-B1 | AMINOMETHYL QUINOLONE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-12-30 | — | — | EP | disclosed |
| EP-2731932-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-05-21 | — | — | EP | disclosed |
| US-8501732-B2 | Aminomethyl quinolone compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501732-B2 | Aminomethyl quinolone compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501732-B2 | Aminomethyl quinolone compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-20130018043-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | BILOTTA JOSEPH A (US) | 2013-01-17 | — | — | US | disclosed |
| WO-2013007676-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |
| US-20130018043-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | BILOTTA JOSEPH A (US) | 2013-01-17 | — | — | US | disclosed |
| WO-2013007676-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |
| US-20130018043-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | BILOTTA JOSEPH A (US) | 2013-01-17 | — | — | US | disclosed |
| US-8163906-B2 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | ROCHE PALO ALTO, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2148862-B1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2012-03-28 | — | — | EP | disclosed |
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |
| US-20080287458-A1 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | ROCHE PALO ALTO LLC | 2008-11-20 | — | — | US | disclosed |
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018043-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | MAP3K1, MAP3K11, MAP3K5 | AKR1C3 2033/4885AKR1C2 1403/4885MAPT 1251/4885 |
| US-20080287458-A1 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | MAPK9, MAPK10, MAPK1 | AKR1C3 1069/4885AKR1C2 1207/4885MAPT 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.