Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954131 | 0.88 | PPARG (0.36) | GPR119YAP1NPC1RAB9AALDH1A1 | |
| SCHEMBL6960968 | 0.87 | GPR119 (0.40) | GPR119SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL7081315 | 0.86 | REN (0.45) | REN | |
| SCHEMBL6949602 | 0.86 | GPR119 (0.39) | GPR119KDM1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7080733 | 0.83 | REN (0.45) | YAP1KDM1AALDH1A1REN | |
| SCHEMBL6043843 | 0.83 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HTR2AGAA | |
| SCHEMBL6960306 | 0.81 | REN (0.35) | GPR119REN | |
| SCHEMBL6956320 | 0.81 | MEN1 (0.40) | GPR119HTR2AGAAKDM1AMAPT | |
| SCHEMBL27488575 | 0.79 | REN (0.44) | REN | |
| SCHEMBL6954247 | 0.79 | REN (0.42) | HTR2AKDM1AALDH1A1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |