Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953331 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL6947834 | 0.92 | THRB (0.44) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL6947838 | 0.92 | THRB (0.44) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL6952750 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL6952751 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL6949544 | 0.87 | PTGS2 (0.47) | ALDH1A1KMT2AMEN1MAPTTDP1 | |
| SCHEMBL6949542 | 0.87 | PTGS2 (0.47) | ALDH1A1KMT2AMEN1MAPTTDP1 | |
| SCHEMBL8008686 | 0.86 | THRB (0.43) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL8008685 | 0.86 | THRB (0.43) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL8428063 | 0.82 | PTGS2 (0.45) | ALDH1A1KMT2AMEN1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | claimed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |