Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13104263 | 0.75 | CNR2 (0.58) | CNR2PKMATMHSD17B10TSHR | |
| SCHEMBL12868284 | 0.75 | CNR2 (0.54) | CNR2PKMATMHSD17B10TSHR | |
| SCHEMBL6948521 | 0.74 | TRPV1 (0.49) | SLC1A1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3538772 | 0.70 | ALDH1A1 (0.54) | CNR2PKMATMHSD17B10TSHR | |
| SCHEMBL13631406 | 0.69 | TSHR (0.50) | CNR2PKMATMHSD17B10TSHR | |
| SCHEMBL6947622 | 0.67 | NAALAD2 (0.45) | SLC1A1KMT2AGRIA1GRIA2GRIA3 | |
| SCHEMBL5290594 | 0.65 | MEN1 (0.72) | CNR2ATMTSHRMEN1KMT2A | |
| SCHEMBL11530868 | 0.64 | PKM (0.41) | CNR2PKMATMHSD17B10MEN1 | |
| SCHEMBL1666146 | 0.64 | SLC1A1 (0.70) | TSHRSLC1A1KMT2AGRIA1GRIA2 | |
| SCHEMBL142983 | 0.64 | SLC1A1 (0.70) | TSHRSLC1A1KMT2AGRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758328-B1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INT LTD (GB) | 2003-07-16 | — | — | EP | disclosed |
| US-5747499-A | CYCLOPENTAQUINAZOLINE COMPOUNDS CYCLOPENTAQUINAZOLINE COMPOUNDS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1998-05-05 | — | — | US | disclosed |
| EP-0758328-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INTERNATIONAL LIMITED (GB) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030673-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |