Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278391 | 0.79 | TTR (0.50) | MAOBTYRCES2ALOX5CA12 | |
| SCHEMBL2198518 | 0.77 | MAOB (0.44) | MAOBTYRCES2ALOX5CA12 | |
| SCHEMBL68212 | 0.75 | MAOB (0.67) | MAOBALDH1A1CA1CA2TSHR | |
| SCHEMBL29692356 | 0.75 | MAOB (0.67) | MAOBALDH1A1CA1CA2TSHR | |
| SCHEMBL16182232 | 0.72 | NPC1 (0.43) | MAOBTYRALOX5ALDH1A1GFER | |
| SCHEMBL5800656 | 0.72 | TTR (0.61) | CA12ALDH1A1CA1CA2CA7 | |
| SCHEMBL61461 | 0.72 | ALDH1A1 (0.41) | MAOBALDH1A1TSHRPTGS1 | |
| SCHEMBL14043320 | 0.72 | BACE1 (0.33) | MAOBALDH1A1ESR1IDO1 | |
| SCHEMBL13914988 | 0.71 | MAOB (0.50) | MAOBTYRCA12ALDH1A1CA1 | |
| SCHEMBL8819670 | 0.71 | MAOB (0.40) | MAOBTYRCES2ALOX5CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150247863-A1 | DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS | Life Technologies Corporation | 2015-09-03 | — | — | US | disclosed |
| US-20140356873-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | LIFE TECHNOLOGIES CORP (US) | 2014-12-04 | — | — | US | disclosed |
| US-8846925-B2 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings | Life Technologies Corporation (US) | 2014-09-30 | — | — | US | disclosed |
| US-20120315661-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | Life Technologies Corporation (US) | 2012-12-13 | — | — | US | disclosed |
| US-8183375-B2 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings | Life Technologies Corporation (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110027800-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | Life Technologies Corporation (US) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110027800-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | CYP3A7, UGT1A7, UGT2B7 | MAOB 1690/4885TYR 465/4885CES2 558/4885 |
| US-20150247863-A1 | DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS | CYP3A7, UGT1A7, UGT2B7 | MAOB 1690/4885TYR 465/4885CES2 558/4885 |
| US-20140356873-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | CYP3A7, UGT1A7, UGT2B7 | MAOB 1690/4885TYR 465/4885CES2 558/4885 |
| US-20120315661-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | CYP3A7, UGT1A7, UGT2B7 | MAOB 1690/4885TYR 465/4885CES2 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.