Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MGAT2 | Q10469 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30555219 | 1.00 | PKLR (0.55) | PKLRGAAIDO1PGRCA12 | |
| SCHEMBL9333808 | 0.83 | IDO1 (0.54) | PKLRIDO1PGRTP53PDE3B | |
| SCHEMBL7812463 | 0.82 | MGAT2 (0.56) | PKLRCA12CA9TP53ALDH1A1 | |
| SCHEMBL20269808 | 0.79 | PGR (0.53) | PGRPDE3BPDE3A | |
| SCHEMBL16849933 | 0.79 | PGR (0.53) | PGRPDE3BPDE3A | |
| SCHEMBL8307129 | 0.77 | PKLR (0.50) | PKLRGAAALDH1A1KDM4EMAPT | |
| SCHEMBL6954598 | 0.77 | GAA (0.63) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7077522 | 0.76 | GAA (0.61) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6951305 | 0.74 | MGAT2 (0.60) | PKLRCA12CA9TP53ALDH1A1 | |
| SCHEMBL6947705 | 0.74 | GAA (0.62) | GAAALDH1A1HSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655518-A | Isatin derivative and preparation method and application thereof | 东南大学 | 2023-08-29 | — | — | CN | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| EP-0988035-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BECKMAN CORP (US) | 2001-09-19 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-29 | — | — | EP | claimed |
| WO-1999006042-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | claimed |
| CN-116655518-A | Isatin derivative and preparation method and application thereof | 东南大学 | 2023-08-29 | — | — | CN | disclosed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-0988035-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BECKMAN CORP (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |
| EP-0988035-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1999006042-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |