Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LIPE | Q05469 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954285 | 1.00 | ALDH1A1 (0.50) | ALDH1A1HPGDSMN1; SMN2TSHRNPC1 | |
| SCHEMBL7067800 | 1.00 | ALDH1A1 (0.50) | ALDH1A1HPGDSMN1; SMN2TSHRNPC1 | |
| SCHEMBL6946641 | 0.88 | MAPT (0.49) | ALDH1A1SMN1; SMN2MAPTLIPEPOLB | |
| SCHEMBL7068432 | 0.88 | MAPT (0.49) | ALDH1A1SMN1; SMN2MAPTLIPEPOLB | |
| SCHEMBL6946636 | 0.88 | MAPT (0.49) | ALDH1A1SMN1; SMN2MAPTLIPEPOLB | |
| SCHEMBL6956637 | 0.88 | LMNA (0.50) | ALDH1A1 | |
| SCHEMBL6956635 | 0.88 | LMNA (0.50) | ALDH1A1 | |
| SCHEMBL7069250 | 0.88 | LMNA (0.50) | ALDH1A1 | |
| SCHEMBL6954395 | 0.86 | XPNPEP2 (0.43) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7068510 | 0.86 | XPNPEP2 (0.43) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268454-A1 | SUCCINOYLAMINO HETEROCYCLES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074796-A1 | SUCCINOYLAMINO HETEROCYCLES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |