SCHEMBL695455

SCHEMBL695455

O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)N2CCSCC2)c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.75
SMN1; SMN2 Q16637 4/20 0.75
KMT2A Q03164 4/20 0.75
MEN1 O00255 3/20 0.75
LMNA P02545 2/20 0.60
L3MBTL1 Q9Y468 3/20 0.58
TDP1 Q9NUW8 3/20 0.58
CTDSP1 Q9GZU7 2/20 0.58
POLB P06746 1/20 0.55
NPSR1 Q6W5P4 2/20 0.54
APOBEC3A P31941 1/20 0.54
APOBEC3G Q9HC16 1/20 0.54
HPGD P15428 1/20 0.54
MCOLN3 Q8TDD5 1/20 0.54
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
RAB9A P51151 1/20 0.52
MAPT P10636 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30892438 0.86 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL3101531 0.84 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL11880773 0.83 ALDH1A1 (0.75) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL695019 0.83 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL13157463 0.81 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL693052 0.80 ALDH1A1 (0.70) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL29432526 0.79 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2KMT2ALMNAL3MBTL1
SCHEMBL11964590 0.78 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL19720320 0.77 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL13108359 0.76 L3MBTL1 (0.51) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2749554-B1 2,5-disubstituted arylsulfonamide CCR3 antagonists SMA THERAPEUTICS INC (US) 2017-12-20 EP disclosed
EP-2749554-B1 2,5-disubstituted arylsulfonamide CCR3 antagonists SMA THERAPEUTICS INC (US) 2017-12-20 EP disclosed
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2016-02-04 US disclosed
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2016-02-04 US disclosed
US-9187425-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-11-17 US disclosed
US-9187425-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-11-17 US disclosed
EP-2749554-A2 2,5-disubstituted arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2014-07-02 EP disclosed
EP-2749554-A2 2,5-disubstituted arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2014-07-02 EP disclosed
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2014-03-06 US disclosed
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2014-03-06 US disclosed
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-03-14 US disclosed
US-8318747-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2012-11-27 US disclosed
US-8318747-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2012-11-27 US disclosed
US-8318747-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2012-11-27 US disclosed
EP-2421830-A2 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS Axikin Pharmaceuticals, Inc. (US) 2012-02-29 EP disclosed
WO-2010123959-A2 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed
WO-2010123959-A2 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed
US-20100273785-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2010-10-28 US disclosed
US-20100273785-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2010-10-28 US disclosed
US-20100273785-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2010-10-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ALDH1A1 1349/4885SMN1; SMN2 603/4885KMT2A 2893/4885
US-20100273785-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ALDH1A1 2329/4885SMN1; SMN2 819/4885KMT2A 2754/4885
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ALDH1A1 1349/4885SMN1; SMN2 603/4885KMT2A 2893/4885
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ALDH1A1 1349/4885SMN1; SMN2 603/4885KMT2A 2893/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.