Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105567 | 1.00 | FKBP1A (0.42) | FKBP1APRMT5WDR77F2PRSS1 | |
| SCHEMBL14974360 | 0.79 | NR1H2 (0.49) | FKBP1APRMT5WDR77F2PRSS1 | |
| SCHEMBL2685496 | 0.79 | NR1H2 (0.49) | FKBP1APRMT5WDR77F2PRSS1 | |
| SCHEMBL2107851 | 0.79 | NR1H2 (0.49) | FKBP1APRMT5WDR77F2PRSS1 | |
| SCHEMBL7968279 | 0.75 | GAA (0.43) | MAPTALDH1A1MMP2LMNA | |
| SCHEMBL2102798 | 0.75 | GAA (0.43) | MAPTALDH1A1MMP2LMNA | |
| SCHEMBL696232 | 0.75 | GAA (0.43) | MAPTALDH1A1MMP2LMNA | |
| SCHEMBL7985048 | 0.75 | GAA (0.43) | MAPTALDH1A1MMP2LMNA | |
| SCHEMBL701211 | 0.74 | PRMT5 (0.45) | FKBP1APRMT5WDR77F2PRSS1 | |
| SCHEMBL7981677 | 0.74 | CTSL (0.39) | MAPTALDH1A1MMP2LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |