Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023701 | 0.83 | GRM1 (0.44) | GRM5GRM1PPARGPPARASIGMAR1 | |
| SCHEMBL4251822 | 0.81 | GRM5 (0.70) | GRM5GRM1PDK4 | |
| SCHEMBL29559340 | 0.81 | GRM5 (0.70) | GRM5GRM1PDK4 | |
| SCHEMBL6953745 | 0.76 | GRM5 (0.44) | GRM5GRM1SIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6957185 | 0.76 | PPARG (0.44) | PPARGPPARASIGMAR1 | |
| SCHEMBL17722891 | 0.75 | GRM5 (0.58) | GRM5GRM1PDK4GPR119 | |
| SCHEMBL6953065 | 0.74 | CYP11B2 (0.36) | GRM5GRM1PDK4GPR119 | |
| SCHEMBL6953740 | 0.73 | NAMPT (0.36) | GRM5GRM1PPARGPPARAPDK4 | |
| SCHEMBL31334406 | 0.73 | GRM5 (0.55) | GRM5GRM1PDK4GPR119 | |
| SCHEMBL6956024 | 0.73 | GRM5 (0.35) | GRM5GRM1PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |