Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 11/20 | 0.33 |
| ▸ | GRM5 | P41594 | 10/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953740 | 0.86 | NAMPT (0.36) | CYP11B2NAMPTGRM1GRM5BTK | |
| SCHEMBL6042259 | 0.81 | CYP11B2 (0.52) | CYP11B2NAMPTGRM1GRM5BTK | |
| SCHEMBL6957185 | 0.77 | PPARG (0.44) | NAMPT | |
| SCHEMBL6953745 | 0.77 | GRM5 (0.44) | NAMPTGRM1GRM5 | |
| SCHEMBL19514111 | 0.74 | GPR119 (0.42) | NAMPTBTKGPR119 | |
| SCHEMBL6954561 | 0.74 | GRM5 (0.49) | GRM1GRM5GPR119PDK4 | |
| SCHEMBL6955999 | 0.73 | S1PR1 (0.42) | NAMPTGRM1GRM5BTK | |
| SCHEMBL6961408 | 0.72 | BRD4 (0.38) | CYP11B2NAMPTGRM1GRM5PDK4 | |
| SCHEMBL7080902 | 0.71 | S1PR1 (0.37) | NAMPTGRM1GRM5BTKGPR119 | |
| SCHEMBL6954499 | 0.71 | SCD5 (0.45) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |