Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21921731 | 0.80 | ACHE (0.33) | ACHEBACE1MEN1CYP3A4KMT2A | |
| SCHEMBL13475722 | 0.79 | — | — | |
| SCHEMBL8948267 | 0.73 | ACHE (0.42) | ACHEBACE1TSHR | |
| SCHEMBL8965243 | 0.73 | ACHE (0.55) | ACHEBACE1 | |
| SCHEMBL8948270 | 0.73 | ACHE (0.42) | ACHEBACE1TSHR | |
| SCHEMBL8965248 | 0.73 | ACHE (0.55) | ACHEBACE1 | |
| SCHEMBL11529289 | 0.73 | ACE2 (0.42) | ACHEBACE1 | |
| SCHEMBL13611716 | 0.72 | ACHE (0.41) | ACHEBACE1ALDH1A1TSHR | |
| SCHEMBL11473461 | 0.72 | CA2 (0.44) | ACHEBACE1ALDH1A1TSHR | |
| SCHEMBL13604829 | 0.72 | ACHE (0.41) | ACHEBACE1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023677-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |