Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952830 | 0.83 | RAB9A (0.47) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL6955056 | 0.82 | PNMT (0.40) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL6947740 | 0.81 | TYMS (0.44) | MAPTHTTKMT2A | |
| SCHEMBL6950817 | 0.81 | TYMS (0.44) | MAPTSMN1; SMN2HTTCYP1A2CYP2C9 | |
| SCHEMBL6953047 | 0.81 | MAPT (0.38) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL6951360 | 0.79 | LMNA (0.42) | MAPTALDH1A1SMN1; SMN2HTTCYP2C19 | |
| SCHEMBL6948442 | 0.78 | CA1 (0.41) | MAPTALDH1A1SMN1; SMN2HTTCYP2C19 | |
| SCHEMBL6435436 | 0.77 | MAPT (0.35) | MAPTALDH1A1SMN1; SMN2HTTCYP1A2 | |
| SCHEMBL6948586 | 0.73 | TYMS (0.44) | MAPTALDH1A1SMN1; SMN2HTTCYP1A2 | |
| SCHEMBL6952355 | 0.73 | KMT2A (0.40) | SMN1; SMN2CYP1A2CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074549-B1 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | HOFFMANN LA ROCHE (CH) | 2003-11-19 | — | — | EP | disclosed |
| US-6218385-B1 | FOR THERAPY OR PROPHYLAXIS OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS SUCH AS EPILEPSY, STROKE, CHRONIC AND ACUTE PAIN, PSYCHOSIS, SCHIZOPHRENIA, ALZHEIMER'S DISEASE, COGNITIVE DISORDERS AND MEMORY DEFICITS | HOFFMANN-LA ROCHE INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1074549-A2 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-07 | — | — | EP | disclosed |