Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | CACNA1F | O60840 | 9/20 | 0.68 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.68 |
| ▸ | CACNA1S | Q13698 | 9/20 | 0.68 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | THPO | P40225 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132512 | 0.96 | POLB (0.75) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7416441 | 0.96 | POLB (0.64) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10668372 | 0.88 | POLB (0.55) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10666490 | 0.88 | CACNA1F (0.57) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10670264 | 0.86 | KMT2A (0.76) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10900830 | 0.86 | MEN1 (0.76) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10364949 | 0.85 | KMT2A (0.65) | POLBADORA3KMT2AMEN1MAPT | |
| SCHEMBL6954075 | 0.84 | POLB (0.93) | POLBKMT2AMEN1LMNATSHR | |
| SCHEMBL10391513 | 0.84 | CACNA1F (0.67) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10599225 | 0.84 | POLB (0.57) | POLBCACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6482841-B1 | Pyridyl compounds and pharmaceutical compositions containing them | CERMOL S.A. (CH) | 2002-11-19 | — | — | US | disclosed |
| EP-1023267-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999019302-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 1999-04-22 | — | — | WO | disclosed |