Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 8/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 7/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 7/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955134 | 0.88 | POLB (0.68) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL10665954 | 0.87 | CACNA1F (0.72) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL7416441 | 0.85 | POLB (0.64) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL7132512 | 0.85 | POLB (0.75) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL10667044 | 0.83 | HIF1A (0.64) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL10668367 | 0.81 | CACNA1C (0.49) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL10670264 | 0.78 | KMT2A (0.76) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL10666490 | 0.77 | CACNA1F (0.57) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL10900830 | 0.76 | MEN1 (0.76) | POLBKMT2ACACNA1CCACNA1FCACNA1D | |
| SCHEMBL11063168 | 0.76 | CACNA1F (0.79) | POLBKMT2ACACNA1CCACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4656181-A | CARDIOTONIC AGENTS | CERMOL S.A. (CH) | 1987-04-07 | — | — | US | claimed |
| US-4727066-A | CARDIOVASCULAR DISORDERS | CERMOL S.A. (CH) | 1988-02-23 | — | — | US | disclosed |
| US-4656181-A | CARDIOTONIC AGENTS | CERMOL S.A. (CH) | 1987-04-07 | — | — | US | disclosed |