Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169272 | 0.82 | SLC22A12 (0.38) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL6171090 | 0.81 | SLC22A12 (0.38) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL3602527 | 0.80 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL6182637 | 0.79 | ESR1 (0.40) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL27701283 | 0.79 | ESR1 (0.39) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7984087 | 0.76 | PDK1 (0.40) | MAPTMEN1KMT2ANPSR1MAPK1 | |
| SCHEMBL7983565 | 0.75 | MEN1 (0.50) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3176719 | 0.74 | TEAD1 (0.53) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL3604069 | 0.74 | TEAD1 (0.43) | MAPTPDE7APDE4APDE4BPDE4C | |
| SCHEMBL3605146 | 0.74 | MERTK (0.46) | MAPTMEN1KMT2ALMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912558-B1 | SUBSTITUTED INDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE (PDE) TYPE IV AND TUMOR NECROSIS FACTOR (TNF) INHIBITORS | PFIZER (US) | 2003-07-09 | — | — | EP | disclosed |
| CN-1080260-C | Substituted indazole derivatives and their use as phosphodiesterase (PDE) type IV and tumor necrosis factor (TNF) inhibitors | PFIZER (US) | 2002-03-06 | — | — | CN | disclosed |
| US-6040329-A | Substituted indazole analogs | PFIZER INC (US) | 2000-03-21 | — | — | US | disclosed |
| CN-1223651-A | Substituted indazole derivatives and their use as phosphodiesterase (PDE) type IV and tumor necrosis factor (TNF) inhibitors | PFIZER (US) | 1999-07-21 | — | — | CN | disclosed |
| EP-0912558-A1 | SUBSTITUTED INDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE (PDE) TYPE IV AND TUMOR NECROSIS FACTOR (TNF) INHIBITORS | PFIZER INC. (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049702-A1 | SUBSTITUTED INDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE (PDE) TYPE IV AND TUMOR NECROSIS FACTOR (TNF) INHIBITORS | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |