Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955461 | 0.99 | GPR132 (0.40) | GPR132ADAMTS4TERTMEN1MAPT | |
| SCHEMBL6955626 | 0.96 | ADAMTS4 (0.39) | GPR132ADAMTS4TERTGPR84GPR119 | |
| SCHEMBL6955477 | 0.81 | GPR132 (0.36) | GPR132ADAMTS4TERTKMT2AGPR84 | |
| SCHEMBL6955460 | 0.80 | NPC1 (0.36) | GPR132ADAMTS4TERTKMT2AGPR84 | |
| Cyclohexane SCHEMBL6955484 | 0.79 | ADAMTS4 (0.39) | GPR132ADAMTS4TERTGPR119NPC1 | |
| Cyclopropane SCHEMBL6955630 | 0.79 | ADAMTS4 (0.39) | GPR132ADAMTS4TERTGPR119NPC1 | |
| Cyclopentane SCHEMBL6955464 | 0.79 | ADAMTS4 (0.39) | GPR132ADAMTS4TERTGPR119NPC1 | |
| SCHEMBL6955620 | 0.78 | NPC1 (0.37) | GPR132ADAMTS4TERTGPR119TYK2 | |
| SCHEMBL6966499 | 0.78 | TERT (0.38) | GPR132TERTMAPTGPR84CSF1R | |
| SCHEMBL6958313 | 0.77 | TERT (0.38) | GPR132TERTMAPTKMT2AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |