Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465042 | 0.79 | KDM4E (0.40) | KDM4EGAADYRK1BGPR3PIM1 | |
| SCHEMBL4548295 | 0.76 | KDM4E (0.37) | KDM4EGPR3PIM1MAPK1ALDH1A1 | |
| SCHEMBL29116723 | 0.74 | CHEK1 (0.53) | KDM4EPDPK1CYP3A4GAALIMK1 | |
| SCHEMBL2488607 | 0.70 | KDM4E (0.58) | KDM4EPDPK1CYP3A4GPR3F12 | |
| SCHEMBL30452163 | 0.68 | KDM4E (0.47) | KDM4EPDPK1CYP3A4GAALIMK1 | |
| SCHEMBL25679882 | 0.68 | GABRA1 (0.62) | LIMK1ALDH1A1 | |
| SCHEMBL28301397 | 0.67 | KDM4E (0.50) | KDM4EPDPK1CYP3A4GAACDK5 | |
| SCHEMBL3080026 | 0.67 | ALDH1A1 (0.50) | KDM4EPDPK1CYP3A4GAAGPR3 | |
| SCHEMBL8465040 | 0.67 | ALDH1A1 (0.42) | KDM4EGPR3PIM1MAPK1ALDH1A1 | |
| SCHEMBL19748987 | 0.66 | KDM4E (0.60) | KDM4EPDPK1CYP3A4GPR3F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421864-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122272-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-10-28 | — | — | WO | disclosed |