Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA7 | P43166 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878351 | 0.82 | MAPT (0.51) | LMNATSHRMAPTCA12CA1 | |
| SCHEMBL229792 | 0.82 | TSHR (0.50) | LMNATSHRMAPTCYP2D6ALDH1A1 | |
| SCHEMBL19821903 | 0.80 | FAAH (0.38) | LMNAMAPTMCL1CA12CA1 | |
| SCHEMBL28315849 | 0.79 | LMNA (0.48) | LMNATSHRMAPTCYP2D6ALDH1A1 | |
| SCHEMBL28875912 | 0.79 | LMNA (0.48) | LMNATSHRMAPTCYP2D6ALDH1A1 | |
| SCHEMBL18152012 | 0.79 | LMNA (0.48) | LMNATSHRMAPTCYP2D6ALDH1A1 | |
| SCHEMBL28727541 | 0.79 | LMNA (0.48) | LMNATSHRMAPTCYP2D6ALDH1A1 | |
| SCHEMBL14508455 | 0.77 | LMNA (0.39) | LMNATSHRMAPTCYP2D6ALDH1A1 | |
| SCHEMBL1012855 | 0.77 | LMNA (0.46) | LMNATSHRMAPTCYP2D6ALDH1A1 | |
| SCHEMBL13635623 | 0.77 | LMNA (0.63) | LMNATSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074550-B1 | Process for the preparation of 3-substituted 4-phenyl-piperidine derivatives | CHEMI SPA (IT) | 2003-01-29 | — | — | EP | disclosed |
| US-6444822-B1 | ANTIDEPRESSANTS | CHEMI S.P.A. (IT) | 2002-09-03 | — | — | US | disclosed |
| EP-1074550-A1 | Process for the preparation of 3-substituted 4-phenyl-piperidine derivatives | CHEMI S.p.A. (IT) | 2001-02-07 | — | — | EP | disclosed |