Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879346 | 0.84 | SLC6A3 (0.43) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL10990350 | 0.80 | SLC6A3 (0.47) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL6122435 | 0.79 | SLC6A3 (0.44) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL8099810 | 0.76 | PNMT (0.36) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL30021683 | 0.75 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL10832210 | 0.74 | ALDH1A1 (0.40) | ALDH1A1LMNAHTTIDO1 | |
| SCHEMBL9734799 | 0.73 | SLC6A3 (0.47) | SLC6A3SLC6A2SLC6A4ALDH1A1HTT | |
| SCHEMBL10373709 | 0.72 | CCR1 (0.45) | ALDH1A1 | |
| SCHEMBL7761458 | 0.72 | SLC6A3 (0.38) | SLC6A3ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL10653616 | 0.71 | AKR1C3 (0.42) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| US-6262046-B1 | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists | PFIZER INC. | 2001-07-17 | — | — | US | disclosed |
| US-6242438-B1 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists | PFIZER INC. | 2001-06-05 | — | — | US | disclosed |