Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.60 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ACACB | O00763 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18906035 | 0.87 | NR4A2 (0.69) | CYP19A1CYP11B1CYP11B2GPR132HTT | |
| SCHEMBL23488238 | 0.85 | PARP10 (0.68) | MAOBCYP19A1CYP11B1CYP11B2GPR132 | |
| SCHEMBL7900713 | 0.84 | CYP19A1 (0.66) | CYP19A1CYP11B1CYP11B2GPR132HTT | |
| SCHEMBL9630106 | 0.84 | ACACB (0.58) | CYP19A1CYP11B1CYP11B2GPR132HTT | |
| SCHEMBL28048524 | 0.84 | MAPK1 (0.64) | CYP19A1CYP11B1CYP11B2MAOAGPR132 | |
| SCHEMBL6959187 | 0.81 | MAOB (0.71) | MAOBMAOAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL42302 | 0.81 | MAOB (1.00) | MAOBMAOAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7900710 | 0.81 | MAOB (0.71) | MAOBMAOAGPR132HTTALDH1A1 | |
| SCHEMBL7256001 | 0.80 | GPR132 (0.61) | CYP19A1CYP11B1CYP11B2GPR132HTT | |
| SCHEMBL6963969 | 0.80 | BRD4 (0.48) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |