Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753074 | 0.86 | GSK3B (0.50) | GSK3BPARP15PARP14PARP10ERCC5 | |
| SCHEMBL5312161 | 0.80 | PTGS1 (0.53) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL203505 | 0.79 | TNKS (0.58) | GSK3BTNKSPARP15PARP14PARP10 | |
| SCHEMBL4307699 | 0.77 | GSK3B (0.52) | GSK3BPTPN1KMT2A | |
| SCHEMBL27865111 | 0.76 | ERCC5 (0.45) | GSK3BTNKSPARP15PARP14PARP10 | |
| SCHEMBL1350830 | 0.75 | GSK3B (0.67) | GSK3BPARP10ERCC5FEN1PTPN1 | |
| SCHEMBL204218 | 0.75 | GSK3B (0.70) | GSK3BPARP15PARP14PARP10ERCC5 | |
| SCHEMBL695829 | 0.74 | PARP10 (0.43) | PTGS1TNKSPARP15PARP14PARP10 | |
| SCHEMBL27881404 | 0.74 | GSK3B (0.49) | GSK3BPARP15PARP14PARP10ERCC5 | |
| SCHEMBL19339679 | 0.74 | ERCC5 (0.48) | GSK3BPTGS1TNKSPARP15PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421855-A1 | DIARYL ETHERS | Tibotec Pharmaceuticals (IE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122162-A1 | DIARYL ETHERS | TIBOTEC PHARMACEUTICALS (IE) | 2010-10-28 | — | — | WO | disclosed |