Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.52 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753074 | 0.91 | GSK3B (0.50) | GSK3BPTPN1KMT2A | |
| SCHEMBL1758965 | 0.82 | PTPN1 (0.51) | GSK3BPTPN1 | |
| SCHEMBL27865128 | 0.80 | GSK3B (0.50) | GSK3BPTPN1USP5KMT2AHDAC3 | |
| SCHEMBL27771167 | 0.79 | TSHR (0.50) | KMT2A | |
| SCHEMBL695598 | 0.77 | GSK3B (0.43) | GSK3BPTPN1KMT2A | |
| SCHEMBL205280 | 0.77 | GSK3B (0.80) | GSK3BPTPN1HDAC3HDAC4HDAC1 | |
| SCHEMBL27992615 | 0.77 | PARP10 (0.42) | KMT2A | |
| SCHEMBL17873488 | 0.75 | PTPN1 (0.61) | GSK3BPTPN1USP5 | |
| SCHEMBL182091 | 0.75 | USP5 (0.61) | GSK3BPTPN1USP5 | |
| SCHEMBL4329868 | 0.74 | ALDH1A1 (0.52) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121535-A2 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA`DEGLI STUDI DI MILANO - BICOCCA (IT) | 2009-10-08 | — | — | WO | disclosed |