Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 7/20 | 0.43 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959350 | 0.89 | HTR6 (0.51) | HTR6RORCTP53MAPTPPARG | |
| SCHEMBL6956072 | 0.85 | PTGDR2 (0.47) | PTGDR2PTGDRHTR6RORCAKR1C3 | |
| SCHEMBL6959196 | 0.78 | HTR6 (0.51) | HTR6RORCTP53MAPTPPARG | |
| SCHEMBL7950689 | 0.74 | PTGDR2 (0.46) | PTGDR2PTGDRHTR6AKR1C3AKR1C2 | |
| SCHEMBL6958670 | 0.73 | HTR6 (0.53) | HTR6RORCTP53MAPTPPARG | |
| SCHEMBL6956546 | 0.70 | HTR6 (0.49) | HTR6TP53MAPTPPARGLMNA | |
| SCHEMBL6952671 | 0.67 | HTR6 (0.53) | HTR6RORCTP53MAPTPPARG | |
| SCHEMBL7072707 | 0.65 | MAPT (0.54) | TP53MAPTPPARGLMNA | |
| SCHEMBL6952676 | 0.65 | CCR2 (0.61) | HTR6RORCTP53MAPTPPARG | |
| SCHEMBL28207564 | 0.64 | HTR6 (0.57) | HTR6TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001935-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-10-08 | — | — | EP | claimed |