Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300362 | 0.83 | MAPT (0.57) | MAPTMAPK10HDAC1HDAC8HDAC6 | |
| SCHEMBL24482841 | 0.80 | PPARG (0.56) | MAPTMAPK10HDAC1HDAC8HDAC6 | |
| SCHEMBL6959350 | 0.76 | HTR6 (0.51) | MAPTPPARGLMNATP53 | |
| SCHEMBL24482780 | 0.74 | CCR2 (0.65) | MAPTMAPK10HDAC1HDAC8HDAC6 | |
| SCHEMBL24482668 | 0.72 | MAPT (0.55) | MAPTMAPK10FABP4PPARGLMNA | |
| SCHEMBL24482672 | 0.72 | MAPT (0.55) | MAPTMAPK10HDAC1HDAC8HDAC6 | |
| SCHEMBL4210031 | 0.72 | THRA (0.60) | MAPTMAPK10PPARG | |
| SCHEMBL27746336 | 0.72 | MAPT (0.55) | MAPTMAPK10HDAC1HDAC8HDAC6 | |
| SCHEMBL24482667 | 0.72 | MAPT (0.54) | MAPTMAPK10HDAC1HDAC8HDAC6 | |
| SCHEMBL24483342 | 0.71 | PPARG (0.56) | MAPTMAPK10HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |