Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of 4-Nitroaniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Nitroaniline SCHEMBL11498181 | 1.00 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL13529022 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL16451 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| SCHEMBL9065915 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL27963818 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL356765 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL7158091 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL702809 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL21825602 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL7158084 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121507167-A | Acidic water system zinc ion battery electrolyte and battery | 重庆大学 | 2026-02-10 | — | — | CN | disclosed |
| CN-112679701-B | Immobilized lysine endopeptidase and preparation method and application thereof | 重庆宸安生物制药有限公司 | 2022-02-25 | — | — | CN | disclosed |
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |