Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 4-Nitroaniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.60 |
| ▸ | CYP19A1 known ✓ | P11511 | 2/20 | 0.60 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.60 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.54 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Nitroaniline SCHEMBL1116326 | 1.00 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL16451 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL27963818 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL13529022 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| SCHEMBL9065915 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL28516856 | 0.95 | ALDH1A1 (0.86) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL7158091 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL356765 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL21825602 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 | |
| 4-Nitroaniline SCHEMBL11498181 | 0.95 | ALDH1A1 (0.95) | ALDH1A1KMT2AMAPTMEN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119874677-B | Imidazolidinone compound, porous organic polymer gel, and preparation methods and applications thereof | 四川大学 | 2025-06-13 | — | — | CN | claimed |
| CN-119874677-A | Imidazolidinone compound, porous organic polymer gel, and preparation methods and applications thereof | 四川大学 | 2025-04-25 | — | — | CN | claimed |
| CN-113163799-B | Corn protein hydrolysate and preparation method thereof | 嘉吉公司 | 2024-12-31 | — | — | CN | claimed |
| CN-118853819-A | Method for detecting gram-negative bacteria based on vancomycin functionalized magnetic bead combined aminopeptidase test paper | 中国农业科学院兰州畜牧与兽药研究所 | 2024-10-29 | — | — | CN | claimed |
| CN-118791389-A | Preparation method of mirabegron intermediate | 山东四环药业股份有限公司 | 2024-10-18 | — | — | CN | claimed |
| CN-114184562-B | Method for measuring urokinase activity by chromogenic substrate method | 北京赛升药业股份有限公司 | 2024-07-26 | — | — | CN | claimed |
| CN-114560779-B | Synthesis method of mirabegron key intermediate | 杭州华东医药集团浙江华义制药有限公司 | 2024-06-25 | — | — | CN | claimed |
| CN-117800905-A | Preparation method of 4- (2, 6-dimethyl-3-nitropyridin-4-ylamino) phenethyl carbamic acid benzyl ester | 洛阳惠中兽药有限公司 | 2024-04-02 | — | — | CN | claimed |
| CN-115043760-B | Method for continuously synthesizing p-nitrobenzenesulfonyl chloride | 中国计量大学 | 2023-08-04 | — | — | CN | claimed |
| CN-110372587-B | Salicylic acid azo 8-hydroxyquinoline and preparation method and application thereof | 莆田学院 | 2022-09-30 | — | — | CN | claimed |
| CN-115043760-A | Method for continuously synthesizing p-nitrobenzenesulfonyl chloride | 中国计量大学 | 2022-09-13 | — | — | CN | claimed |
| CN-114728008-A | Compounds for identifying beta-lactamases and methods of use thereof | 加利福尼亚大学董事会 | 2022-07-08 | — | — | CN | claimed |
| CN-114560779-A | Synthesis method of mirabegron key intermediate | 杭州华东医药集团浙江华义制药有限公司 | 2022-05-31 | — | — | CN | claimed |
| CN-106979928-A | The assay method of noxious material monomethyl amine in air | 江苏三联安全评价咨询有限公司 | 2017-07-25 | — | — | CN | claimed |
| CN-121270488-A | Method for continuously preparing mirabegron by micro-channel reactor | 浙江工业大学 | 2026-01-06 | — | — | CN | disclosed |
| US-20250382390-A1 | ANTIBODY VARIANT AND ISOFORM WITH LOWERED BIOLOGICAL ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2025-12-18 | — | — | US | disclosed |
| US-20250382387-A1 | MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2025-12-18 | — | — | US | disclosed |
| US-4119620-A | Novel dipeptide derivatives, salts thereof, and method of measuring enzyme activity | AJINOMOTO CO., INC. (JP) | 1978-10-10 | — | — | US | disclosed |
| US-3963730-A | ACID CATALYST | SANKYO COMPANY LIMITED (JA) | 1976-06-15 | — | — | US | disclosed |
| US-3959298-A | ACETONINE WITH WATER IN ACID CATALYST | SANKYO COMPANY LIMITED (JA) | 1976-05-25 | — | — | US | disclosed |