Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20523370 | 0.92 | GPR119 (0.43) | ALDH1A1NR1H2KDM4EGPR119USP2 | |
| SCHEMBL6951547 | 0.88 | NR1H2 (0.46) | NR1H2GPR119USP2SMN1; SMN2HPGD | |
| SCHEMBL310402 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KDM4EGPR119USP2SMN1; SMN2 | |
| SCHEMBL7814135 | 0.85 | NR1H2 (0.43) | NR1H2GPR119USP2SMN1; SMN2HPGD | |
| SCHEMBL6958889 | 0.85 | GAA (0.47) | ALDH1A1NR1H2GPR119USP2SMN1; SMN2 | |
| SCHEMBL56379 | 0.82 | USP2 (0.53) | GPR119USP2SMN1; SMN2HPGD | |
| SCHEMBL6963497 | 0.82 | SMN1; SMN2 (0.52) | NR1H2GPR119USP2SMN1; SMN2 | |
| SCHEMBL21302145 | 0.81 | NR1H2 (0.46) | ALDH1A1NR1H2KDM4EGPR119USP2 | |
| SCHEMBL24359058 | 0.81 | NR1H2 (0.49) | ALDH1A1NR1H2KDM4EGPR119USP2 | |
| SCHEMBL15664395 | 0.81 | HPGD (0.51) | ALDH1A1NR1H2KDM4EGPR119USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790248-B1 | 3-Aza-piperidone- (tetrahydropyrimidin-2-one) and 3-oxa-piperidone (1,3 oxazin-2-one) derivatives, their preparation and their use as tachykinin/neurokinin antagonists | PFIZER LTD (GB) | 2003-05-28 | — | — | EP | disclosed |
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| US-6242438-B1 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists | PFIZER INC. | 2001-06-05 | — | — | US | disclosed |
| EP-0775132-B1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| CN-1207096-A | 3-azetidinylalkylpiperidines or-pyrrolidines as tachykinin antagonists | PFIZER RES & DEV (IE) | 1999-02-03 | — | — | CN | disclosed |
| US-5846965-A | 3-aza and 3-oxa piperidone tachykinin antagonists | PFIZER INC. (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0790248-A1 | 3-Aza-piperidone- (tetrahydropyrimidin-2-one) and 3-oxa-piperidone (1,3 oxazin-2-one) derivatives, their preparation and their use as tachykinin/neurokinin antagonists | Pfizer Limited (GB) | 1997-08-20 | — | — | EP | disclosed |
| EP-0775132-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | Pfizer Limited (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005193-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |