Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.35 |
| ▸ | TGM1 | P22735 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951547 | 0.85 | NR1H2 (0.46) | NR1H2SMN1; SMN2USP2GPR119HPGD | |
| SCHEMBL6957235 | 0.85 | ALDH1A1 (0.46) | NR1H2SMN1; SMN2USP2ALDH1A1GPR119 | |
| SCHEMBL6853359 | 0.84 | GAA (0.64) | GAATGM2SMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL7814135 | 0.81 | NR1H2 (0.43) | NR1H2TGM2SMN1; SMN2USP2GPR119 | |
| SCHEMBL20523370 | 0.80 | GPR119 (0.43) | GAANR1H2TGM2SMN1; SMN2USP2 | |
| SCHEMBL6963497 | 0.79 | SMN1; SMN2 (0.52) | NR1H2SMN1; SMN2USP2GPR119L3MBTL1 | |
| SCHEMBL21302145 | 0.78 | NR1H2 (0.46) | NR1H2SMN1; SMN2USP2ALDH1A1GPR119 | |
| SCHEMBL24359058 | 0.78 | NR1H2 (0.49) | NR1H2SMN1; SMN2USP2ALDH1A1GPR119 | |
| SCHEMBL15664395 | 0.78 | HPGD (0.51) | NR1H2SMN1; SMN2USP2ALDH1A1GPR119 | |
| SCHEMBL26101858 | 0.77 | NR1H2 (0.45) | NR1H2SMN1; SMN2USP2ALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791592-B1 | Azetidines | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6022971-A | Azetidines | PFIZER INC (US) | 2000-02-08 | — | — | US | disclosed |
| US-5741790-A | Azetidines | PFIZER INC. (US) | 1998-04-21 | — | — | US | disclosed |
| EP-0791592-A2 | Azetidines | Pfizer Limited (GB) | 1997-08-27 | — | — | EP | disclosed |