SCHEMBL7086664

SCHEMBL7086664

CCn1c(CN)nc(C(C)C)c1Sc1cccc(F)c1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.35
DHFR P00374 1/20 0.34
HAO1 Q9UJM8 1/20 0.33
KMT2A Q03164 1/20 0.32
ATM Q13315 1/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
GCGR P47871 1/20 0.32
TYMS P04818 1/20 0.32
NOTUM Q6P988 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
SLC6A9 P48067 4/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
EPHX1 P07099 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7086943 0.91 TAAR1 (0.34) DHODHDHFRHAO1KMT2AATM
SCHEMBL6974771 0.88 DHODH (0.43) DHODHDHFRHAO1KMT2AATM
SCHEMBL6975880 0.88 ALDH1A1 (0.32) ALDH1A1LMNAMAPT
SCHEMBL6964947 0.86 DHODH (0.34) DHODHDHFRHAO1KMT2AATM
SCHEMBL6973489 0.86 GCGR (0.38) DHODHDHFRHAO1KMT2AATM
SCHEMBL6974210 0.86 DHODH (0.34) DHODHDHFRHAO1KMT2AATM
SCHEMBL6966003 0.86 TYMS (0.37) DHFRKMT2ATYMSALDH1A1LMNA
SCHEMBL7083044 0.86 DHODH (0.34) DHODHDHFRHAO1KMT2AATM
SCHEMBL6973797 0.86 MAOA (0.38) HAO1MAOAMAOBGCGRTYMS
SCHEMBL6969333 0.85 DHODH (0.33) DHODHDHFRHAO1KMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed