Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 3/20 | 0.39 |
| ▸ | CTSA | P10619 | 12/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8751749 | 0.80 | CTSA (0.43) | CTSAALDH1A1 | |
| SCHEMBL30229840 | 0.78 | F2RL1 (0.50) | F2RL1 | |
| SCHEMBL8185892 | 0.76 | CTSA (0.35) | CTSA | |
| SCHEMBL5548986 | 0.75 | ADRA2A (0.42) | F2RL1KDM4EALDH1A1 | |
| SCHEMBL6952503 | 0.71 | MTOR (0.44) | F2RL1KDM4EALDH1A1 | |
| SCHEMBL6953469 | 0.71 | F2RL1 (0.36) | F2RL1 | |
| SCHEMBL9050278 | 0.70 | CTSA (0.43) | CTSA | |
| SCHEMBL8194218 | 0.68 | CTSA (0.36) | CTSACNR1 | |
| SCHEMBL6954666 | 0.68 | F2RL1 (0.43) | F2RL1 | |
| SCHEMBL9049736 | 0.68 | CTSA (0.41) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276725-A2 | 5-SUBSTITUTED TETRALONES AS INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001079180-A2 | 5-SUBSTITUTED TETRALONES AS INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |
| EP-1025088-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999020611-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |