Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 7/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6953097 | 0.99 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6962162 | 0.89 | MAPT (0.50) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL6954185 | 0.87 | MAPT (0.49) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL8115088 | 0.82 | CRHR1 (0.43) | MAPTSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL27836600 | 0.74 | ELANE (0.43) | NPC1RAB9ASMN1; SMN2KMT2ACRHR1 | |
| SCHEMBL31586325 | 0.72 | KDM4E (0.59) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL18903097 | 0.72 | KDM4E (0.59) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL27854700 | 0.71 | FAAH (0.40) | NPC1RAB9AALDH1A1 | |
| SCHEMBL27854632 | 0.71 | FAAH (0.40) | NPC1RAB9AALDH1A1 | |
| SCHEMBL27836590 | 0.71 | FAAH (0.40) | NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929299-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA(b)BENZOFURANS | LILLY CO ELI (US) | 2003-10-08 | — | — | EP | disclosed |
| US-5935992-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-08-10 | — | — | US | disclosed |
| US-5932739-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-08-03 | — | — | US | disclosed |
| US-5846995-A | Substituted 1, 2, 3, 4-tetrahydro-2-dibenzofuranamines and 2-amino-cyclohepta (6, 7-B) Benzofurans | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |