Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6954185 | 0.99 | MAPT (0.49) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6958003 | 0.89 | MAPT (0.47) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL6953097 | 0.87 | MAPT (0.46) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8111024 | 0.81 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL6958348 | 0.77 | MEN1 (0.49) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL7379709 | 0.76 | MAOA (0.53) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL31586325 | 0.74 | KDM4E (0.59) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18903097 | 0.74 | KDM4E (0.59) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL23823627 | 0.71 | MAPT (0.59) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16559118 | 0.70 | MAPT (0.38) | MAPTALDH1A1SMN1; SMN2HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929299-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA(b)BENZOFURANS | LILLY CO ELI (US) | 2003-10-08 | — | — | EP | disclosed |
| US-5935992-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-08-10 | — | — | US | disclosed |
| US-5932739-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-08-03 | — | — | US | disclosed |
| US-5846995-A | Substituted 1, 2, 3, 4-tetrahydro-2-dibenzofuranamines and 2-amino-cyclohepta (6, 7-B) Benzofurans | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |