Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA5A | P35218 | 1/20 | 0.63 |
| ▸ | CA7 | P43166 | 1/20 | 0.63 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961718 | 0.86 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ATAAR1KMT2A | |
| SCHEMBL6961756 | 0.85 | KMT2A (0.67) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4153733 | 0.84 | HPGD (0.79) | SMN1; SMN2TAAR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10570417 | 0.84 | ALDH1A1 (0.78) | SMN1; SMN2RAB9AKMT2AMEN1MAPT | |
| SCHEMBL8192655 | 0.84 | KMT2A (0.66) | SMN1; SMN2NPC1RAB9ATAAR1KMT2A | |
| SCHEMBL7824219 | 0.82 | ALDH1A1 (0.53) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2510372 | 0.82 | KMT2A (0.56) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL1395699 | 0.82 | CNR1 (0.60) | SMN1; SMN2NPC1RAB9ATAAR1KMT2A | |
| SCHEMBL20718868 | 0.82 | ALDH1A1 (0.60) | SMN1; SMN2NPC1RAB9ATAAR1KMT2A | |
| SCHEMBL17117203 | 0.82 | NPC1 (0.67) | SMN1; SMN2NPC1RAB9ATAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727212-A | A kind of synthesis of Mirabegron intermediate (R) -2- hydroxy-ns-(4- nitrophenethyls) -2- phenyl-acetamides | 安徽德信佳生物医药有限公司 | 2018-11-02 | — | — | CN | disclosed |
| WO-2015044965-A1 | A PROCESS FOR PREPARATION OF MIRABEGRON AND ALPHA CRYSTALLINE FORM THEREOF | MEGAFINE PHARMA (P) LTD. (IN) | 2015-04-02 | — | — | WO | disclosed |
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |